For an oocyte for being Prepared for fertilization and expansion into an embryo, the right list of genes really should be turned on. Namekawa suspected this pre-programming with the oocyte genome happens in a number of stages — the main just one starting off around the time a female is born. He thought that chromatin remodeling proteins did A lot of the get the job done, by shifting spools about.
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This protein may “create and preserve the chromatin point out,” states Namekawa — holding the spools in position and the oocytes genetically primed as being the mouse matures.
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